PNC-27

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(10mg) PNC-27 is a membrane-active peptide for in vitro anticancer research applications that selectively kills cancer cells by binding to HDM-2 on their membranes and inducing necrosis through pore formation.

Buy 10 vials and get 15% Discount.

For wholesale orders, contact us at wholesale@pristineaminos.com

Original price was: $279.97.Current price is: $195.98.

PNC-27 Product Description

PNC-27 is a synthetic peptide designed to selectively kill cancer cells by targeting a protein called HDM-2 (also known as MDM2) found on the membranes of many cancer cells. It works by binding to membrane-bound HDM-2, forming pores in the cancer cell membrane, and causing rapid cell death through necrosis, while sparing normal cells.

PNC-27 is derived from the p53 protein’s HDM-2 binding domain (amino acids 12-26) and is linked to a membrane-penetrating sequence, allowing it to enter and act on cancer cell membranes. The peptide binds specifically to HDM-2 present on the surface of cancer cells, not normal cells. This binding leads to the formation of transmembrane pores, disrupting the cell membrane and causing cell lysis and necrosis, independent of the p53 pathway.

Research Use Only – Legal Disclaimer

All products on this site are for research and development use only. All products are sold for research, laboratory, or analytical purposes only, and are not for human consumption. Products are not for human consumption of any kind. The statements made on this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure, or prevent any disease. Alpha Omega Peptide is a chemical supplier. Alpha Omega Peptide is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Alpha Omega Peptide is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.

1. What are peptides used for?